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- Abemaciclib (CDK4/6 Inhibitor) A therapy that blocks proteins involved in cell division.
- Academic Medical Center A hospital affiliated with a university combining care, research, and teaching.
- Accelerated Research Scientific progress occurring more rapidly through targeted support.
- Alex’s Lemonade Stand Foundation R Accelerated Award Funding for childhood cancer research projects.
- BET Inhibitor A drug that blocks BET proteins to suppress cancer growth.
- Biomarker A biological indicator of disease or treatment response.
- Carboplatin/Paclitaxel A chemotherapy drug combination.
- Care Preferences Documented patient wishes for treatment approach.
- Case Reports Detailed descriptions of individual patient treatments and outcomes.
- CDK4/6 Inhibitor A drug targeting proteins involved in cancer cell proliferation.
- Chromatin A complex of DNA and proteins in the cell nucleus that helps regulate gene expression.
- Clinical Trial A research study testing new ways to prevent, detect, or treat diseases.
- Clinical Trial Coordinator Person managing clinical trial logistics.
- ClinicalTrials.gov A public database listing clinical trials.
- Combined Modality Therapy Use of two or more treatments together.
- Comprehensive Monitoring Close tracking of health during a trial.
- Computational Immunology A field using data science to study the immune system.
- CPRIT Scholar An award from the Cancer Prevention and Research Institute of Texas.
- Dana-Farber Cancer Institute A leading cancer treatment and research center in Boston.
- Developmental Therapeutics Research focused on discovering and developing new treatments.
- Eligibility Criteria Requirements for joining a clinical trial.
- Etoposide and Cisplatin Chemotherapy drugs used in combination.
- Experimental Treatment A treatment not yet approved for general use.
- Fusion Oncogene A hybrid gene formed from two previously separate genes, often seen in cancers like NUT carcinoma.
- Genetic Alterations DNA changes that may affect disease or treatment.
- Genetic Characteristics Inherited or acquired DNA traits of a tumor.
- Genetic Profile The unique set of genetic features in an individual or tumor.
- Head and Neck Oncology Specialty treating cancers in the head and neck area.
- High-Risk, High-Reward Research Innovative research with high potential and uncertainty.
- Hope vs. Realism Balancing optimism with practical understanding.
- Ifosfamide-Based Regimen A chemotherapy treatment plan using ifosfamide.
- Immunogenomics The study of how genetics influence the immune response.
- Immunohistochemistry (IHC) A test to detect specific proteins in tissue.
- Immunotherapy A cancer treatment that helps the immune system recognize and attack cancer cells.
- Informed Consent Process of understanding and agreeing to trial participation.
- Instincts as a Caregiver A caregiver’s deep understanding of their loved one's needs.
- Laboratory Models Tools for studying diseases in lab settings.
- Meal Train A coordinated effort to provide meals during medical crises.
- Medical Oncologist A doctor who treats cancer using medication.
- Medical Oncology A branch of medicine focused on diagnosing and treating cancer with medications.
- Micro-Break Short, intentional breaks to reset during caregiving.
- Molecular Characteristics Biological markers at a molecular level.
- Multimodal Treatment Combining multiple treatments like surgery and chemotherapy.
- NIH Director's Early Independence Award A prestigious NIH grant supporting early-career researchers.
- NUT Carcinoma A rare and aggressive cancer defined by a genetic fusion involving the NUTM1 gene, often affecting the midline structures of the body.
- Oncogene A gene that has the potential to cause cancer.
- Pathology The study of diseases, including their causes and effects, often used to diagnose cancer.
- Pathology Report A medical report based on tissue examination.
- Patient Advocacy Organization A nonprofit supporting patients through education and resources.
- Pattern.org A platform for patients to donate tumor tissue to researchers.
- PD-L1 Status A marker that may predict immunotherapy response.
- Pediatric Oncology Cancer care focused on children.
- Performance Status A measure of a patient's ability to perform daily activities.
- Personalized Immunotherapy Research Lab (PIRL) A lab focused on tailoring immune-based therapies.
- Personalized Medicine Medical care tailored to an individual's genetic and molecular profile.
- Phase 1 Trial Initial testing of a new treatment to determine safety.
- Phase 2 Trial Testing that focuses on whether the treatment works.
- Philanthropic Investment Charitable funding to support scientific progress.
- Preclinical Research Lab research before human testing.
- Private Funding Non-government financial support for research.
- Public Research Grants Government funds for medical and scientific studies.
- Quality of Life (QoL) Overall well-being during or after illness.
- Rare Cancer A cancer affecting fewer than 200,000 people annually in the U.S.
- Rare Cancer Research Foundation A nonprofit accelerating research for rare cancers.
- Registry A centralized database collecting information about individuals with a specific disease.
- Research Infrastructure Systems and tools supporting scientific research.
- Resistance When a tumor stops responding to treatment.
- Scandinavian Ewing Sarcoma SSG IX Regimen A chemotherapy protocol adapted for certain rare cancers.
- Screening Reviewing eligibility for a trial.
- Self-Referral When a patient contacts a trial site on their own.
- Side Effects Unintended effects of a treatment.
- Sontag Foundation Distinguished Scientist Award A research grant awarded to innovative cancer researchers.
- Specialized Testing Advanced diagnostics like genetic sequencing used for rare cancers.
- Standard Care Costs Routine care expenses billed to insurance.
- Standard of Care A guideline for the typical treatment of a medical condition.
- Subtypes Different genetic forms of a disease.
- Supportive Care Treatments to improve comfort and well-being.
- Systemic Therapy Treatment that affects the whole body.
- Targeted Therapy Drugs that target cancer-specific molecules.
- Therapeutic Journaling Writing used as a tool for emotional wellness.
- Thoracic Oncology A medical specialty focusing on cancers of the chest area.
- Tissue Samples Biological material collected for research.
- Treatment Development The process of creating and testing new medical treatments.
- Treatment Response How a tumor reacts to a therapy.
- Trial Sponsor The organization funding a clinical trial.
- Tumor Bank A facility storing tissue samples for research.
- Tumor Features Specific biological aspects of a tumor.
- ZEN003694 An experimental BET inhibitor drug.